Although a Red Devils victory would mark the team's 100th victory over the Gunners in all competitions, the North London powerhouses might win back-to-back Premier League games at Old Trafford for the first time.
An Iberian manager in his 30s is in charge of one of the most prosperous clubs in England's history and is having difficulty motivating a quick turnaround. Although Ruben Amorim has previously acknowledged that he does not anticipate receiving the Mikel Arteta treatment from his superiors, these criteria might be used to any of Sunday's sides.
Amorim may never be far from the axe as long as Man United's dismal performance persists, and the less said about their domestic season overall the better. This is despite the fact that the current Arsenal manager was given plenty of time and resources to make the Gunners a title contender once more.
In addition to finishing in a pitiful 14th place in the Premier League standings, Fulham and their own former Gunner Bernd Leno destroyed Man United's FA Cup championship defense last weekend, meaning that the Europa League will be their last chance to salvage a miserable season.
Amorim's team has only won two of their last seven games across all competitions, and neither of those wins over Ipswich Town or Leicester City was particularly convincing. However, a 1-1 draw with Real Sociedad in Thursday's last-16 first leg at least puts them in a strong position before next week's rematch.
Exorcising those demons could enable the hosts to celebrate victory number 100 over their red-and-white rivals. In addition, the 20-time English champions have lost six of their last seven top-flight games at Old Trafford and have failed to win consecutive Premier League games this season.
Arteta will make it 200 in the Gunners chair as Man United tries to make it 100 against Arsenal. The Spaniard is looking for a 119th victory to go along with reaching a double-century of Premier League games as manager of Sunday's visitors.
The only four players with more than 118 victories from their first 200 games in the tournament are Sir Alex Ferguson, Pep Guardiola, Jose Mourinho, and Jurgen Klopp. However, each of those four players has something the Gunners manager does not: a Premier League championship as head coach.
The Spaniard's challenging wait to bring another Premier League title to North London appears to be going on for at least another year. Their inability to score against West Ham United and Nottingham Forest has left them 13 points behind Liverpool, whose lead will increase to 16 on Saturday unless they manage to defeat Southampton at home.
As they get ready for an inevitable quarterfinal matchup with either Atletico Madrid or Real Madrid, Arsenal, however, defied their selection dilemma in the final third to thrash PSV Eindhoven 7-1 in midweek, becoming the first team to ever score seven goals away from home in a Champions League knockout game.
If Arteta's revitalized attackers are to continue their incredible recent run against Man United, who have lost all four of their league games against the Gunners, including a 1-0 loss in this precise matchup last year, they will need to be playing at their best.
As a result, the visitors are only ninety minutes away from winning back-to-back league games at Old Trafford, something they have not done since 1979. However, the FA Cup third-round defeat to Amorim's team in January gives optimism to both the red half of Manchester and Merseyside.